Synonyms: pyrifazimine
Compound class:
Synthetic organic
Comment: TBI-166 is a riminophenazine class antimycobacterial compound and an analogue of clofazimine [1]. TBI-166 has advanced to clinical evaluation for the treatment of tuberculosis.
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Bioactivity Comments |
The MIC for antimycobacterial activity in vitro is 0.016 μg/ml against Mycobacterium tuberculosis H37Rv and 0.027-0.095 μg/ml against a panel of drug-resistant M. tuberculosis clinical isolates [1]. In vivo testing in mice has shown that the drug causes less skin discoloration than clofazimine [2]. |