Synonyms: BTZ-10526043 | MMV676603
Compound class:
Synthetic organic
Comment: BTZ-043 is the lead from a novel class of benzothiazinone compounds with antimycobacterial activity [1], that is is under clinical evaluated as a treatment for tuberculosis (TB). It is an inhibitor of decaprenylphosphoryl-beta-D-ribose oxidase (DprE1), an essential mycobacterial cell wall biosynthesis enzyme [1-3].
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Bioactivity Comments |
The MIC for activity against Mycobacterium tuberculosis H37Rv is 1 ng/ml in vitro [1]. |