TK-HR peptide   Click here for help

GtoPdb Ligand ID: 13042

Synonyms: tachykinin-HR
Compound class: Peptide or derivative
Comment: This is an eleven amino acid (aa) linear peptide that was isolated from the skin of Hoplobatrachus Rugulosus frogs [1]. The peptide sequence is KPNPDRFYGLM-NH2. Its carboxy terminal region contains the tachykinin consensus sequence FxGLM. TK-HR is highly homologous to tachykinin peptides isolated from other frog species, Theloderma kwangsiensis (TK-The1; one aa difference) and Hyla simplex (TK-H1; 2 aa differences).
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CC(C)C[C@@]([H])(C(=O)N[C@@]([H])(CCSC)C(=O)O)NC(=O)CNC(=O)[C@]([H])(CC1=CC=C(C=C1)O)NC(=O)[C@]([H])(CC2=CC=CC=C2)NC(=O)[C@]([H])(CCCNC(=N)N)NC(=O)[C@]([H])(CC(=O)O)NC(=O)[C@]3([H])CCCN3C(=O)[C@]([H])(CC(=O)N)NC(=O)[C@]4([H])CCCN4C(=O)[C@]([H])(CCCCN)N
Isomeric SMILES N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N2[C@@]([H])(CCC2)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC3=CC=CC=C3)C(=O)N[C@@]([H])(CC4=CC=C(O)C=C4)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCSC)C(=O)O
InChI InChI=1S/C61H92N16O16S/c1-34(2)28-41(53(85)71-40(60(92)93)22-27-94-3)69-49(80)33-68-51(83)42(30-36-18-20-37(78)21-19-36)72-54(86)43(29-35-12-5-4-6-13-35)73-52(84)39(15-9-24-67-61(65)66)70-55(87)44(32-50(81)82)74-56(88)47-17-11-26-77(47)59(91)45(31-48(64)79)75-57(89)46-16-10-25-76(46)58(90)38(63)14-7-8-23-62/h4-6,12-13,18-21,34,38-47,78H,7-11,14-17,22-33,62-63H2,1-3H3,(H2,64,79)(H,68,83)(H,69,80)(H,70,87)(H,71,85)(H,72,86)(H,73,84)(H,74,88)(H,75,89)(H,81,82)(H,92,93)(H4,65,66,67)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1
InChI Key HRAVGCUMTINGJJ-CIRMSXBNSA-N
Bioactivity Comments
TK-HR is reported to enhance wound healing in in vitro and in vivo models, via activation of the NK1 receptor (TACR1) and the MAPK and TGF-β/Smad signaling pathways [1]. It exhibits significant modulatory effects on the biological functions of many cell types that are involved in the inflammatory, proliferative, and remodeling stages of wound healing (including macrophages, neutrophils, endothelial cells, and keratinocytes). The wound-healing properties of TK-HR are negated in the presence of the selective NK1 receptor antagonist aprepitant.