Compound class:
Synthetic organic
Comment: HSGN-218 is the lead compound from a series of halogenated N-(1,3,4-oxadiazol-2-yl)benzamides with potent antibacterial activity against Gram-positive bacteria, including Clostridioides difficile [1].
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Bioactivity Comments |
The in vitro antibacterial activity of HSGN-218, against clinically relevant Clostridioides difficile strains (MIC in the range of 0.007-0.07 μM), is more potent than vancomycin [1]. HSGN-218 has been shown to have activity against other Gram-positive bacteria including vancomycin-resistant strains of Enterococcus faecium and Enterococcus faecalis [1] and methicillin-resistant Staphylococcus aureus (MRSA) [2]. The compound has a favourable safety profile, with 100% viability of Caco-2 cells at 64 μg/ml (>9000x of MIC) and is predicted to be restricted to the gut by virtue of its permeability properties [1]. |