Synonyms: OPC-167832
Compound class:
Synthetic organic
Comment: Quabodepistat is a 3,4-dihydrocarbostyril derivative. It is an inhibitor of decaprenylphosphoryl-beta-D-ribose oxidase (DprE1), an essential mycobacterial cell wall biosynthesis enzyme, and has potent antimycobacterial activity [3]. Quabodepistat is under clinical development by Otsuka Pharmaceutical (Tokyo, Japan) as a treatment for tuberculosis (TB).
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Bioactivity Comments |
The MIC for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv is 0.5 ng/ml and against other members of the M. tuberculosis complex the range is 0.5-2.0 ng/ml [3]. |