fluoxetine

Ligand id: 203

Name: fluoxetine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: fluoxetine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 21.26
Molecular weight 309.13
XLogP 6.38
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
5-HT2B receptor Antagonist Antagonist 5.3 pKi - 9
pKi 5.3 [9]
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
CaCC Channel blocker - - - -
Selectivity at human transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
SERT Inhibitor Inhibition 8.5 pKi - 10
pKi 8.5 (Ki 3x10-9 M) [10]
Plasma membrane monoamine transporter Inhibitor Inhibition 4.6 pKi - 3,11
pKi 4.6 (Ki 2.27x10-5 M) [3,11]
Selectivity at mouse ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Kir3.2 Gating inhibitor Antagonist 4.1 – 4.8 pIC50 - 5
pIC50 4.1 – 4.8 [5]
Voltage: -70.0 mV
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
5-HT2C receptor Antagonist Antagonist 7.3 pKi - 9
pKi 7.3 [9]
5-HT2A receptor Antagonist Antagonist 6.5 pKi - 9
pKi 6.5 [9]
5-HT6 receptor Antagonist Antagonist 5.8 pKi - 6
pKi 5.8 [6]
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Kv3.1 Gating inhibitor - 6.1 pIC50 - 2
pIC50 6.1 [2]