cyanotriphenylborate

Ligand id: 2368

Name: cyanotriphenylborate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 23.79
Molecular weight 268.13
XLogP 7.54
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Glycine Receptor (All subtypes) N/A Subunit-specific Inhibition - - < 1x10-6 1
Conc range: < 1x10-6 M α1 > α2 [1]
glycine receptor α1 subunit Hs Channel blocker - 5.9 pIC50 - 1
pIC50 5.9 (IC50 1.3x10-6 M) [1]
Glycine Receptor (All subtypes) Hs Channel blocker - 5.9 pIC50 < 1x10-6 1
pIC50 5.9 Conc range: < 1x10-6 M [1]
glycine receptor β subunit Rn Channel blocker - 5.1 – 5.6 pIC50 - 1
pIC50 5.6 (IC50 2.8x10-6 M) when co-expressed with the human α1 subunit [1]
pIC50 5.1 (IC50 7.5x10-6 M) when co-expressed with the human α2 subunit [1]
glycine receptor α2 subunit Hs Channel blocker - >4.7 pIC50 - 1
pIC50 >4.7 (IC50 <2x10-5 M) [1]