Ligand id: 2438

Name: BTP2

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 100.94
Molecular weight 421.04
XLogP 5.31
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
TRPM4 Hs Activator Agonist 8.1 pEC50 - 3
pEC50 8.1 (EC50 8x10-9 M) [3]
Voltage: -80.0 mV
TRPC3 Hs Channel blocker Antagonist 6.5 pIC50 - 1
pIC50 6.5 (IC50 3x10-7 M) [1]
Voltage: -80.0 mV
TRPC5 Hs Channel blocker - - - -