1,25-dihydroxyvitamin D3

Ligand id: 2779

Name: 1,25-dihydroxyvitamin D3

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: calcitrol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 60.69
Molecular weight 416.33
XLogP 6.75
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Natural/Endogenous Targets
Vitamin D receptor
Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Vitamin D receptor Hs Agonist Agonist 8.9 – 9.2 pKd - 1-2
pKd 8.9 – 9.2 [1-2]
Targets where the ligand is described in the comment field
Target Comment