compound 2d [PMID: 7629799]

Ligand id: 3060

Name: compound 2d [PMID: 7629799]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 10
Topological polar surface area 134.68
Molecular weight 354.14
XLogP 1.77
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
squalene synthase Rn Inhibitor Inhibition 8.6 pIC50 - 1
pIC50 8.6 (IC50 2.6x10-9 M) [1]
Description: Inhibition rat liver microsomal squalene synthase