diphosphoglycolyl proline

Ligand id: 3206

Name: diphosphoglycolyl proline

Abbreviated name: DPGP

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 7
Rotatable bonds 5
Topological polar surface area 215.68
Molecular weight 335.02
XLogP -4.93
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
diphosphomevalonate decarboxylase Inhibitor Competitive 8.6 pKi - 1
pKi 8.6 (Ki 2.3x10-9 M) [1]
Description: recombinant enzyme expressed in E coli, purified, in vitro spectrophotometric assay
Conditions: The concentration of mevalonate 5-diphosphate varied between 86- 285µM. ATP concentration constant at ~8mM. pH 7.0, 30ÂșC