Ligand id: 4153

Name: CFTRinh-172

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 115
Molecular weight 409.01
XLogP 5.7
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
CFTR Hs Channel blocker (intracellular CFTRinh-172) - - - -
intracellular application prolongs mean closed time