Synonyms: H 168/68 | Losec® | Prilosec®
omeprazole is an approved drug (FDA (1989))
Compound class:
Synthetic organic
Comment: This approved drug omeprazole is a racemic mixture of the R and S stereoisomers. Omeprazole is a potassium-transporting ATPase inhibitor, commonly referred to as a proton pump inhibitor.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: omeprazole |
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Bioactivity Comments |
The only bioactivity data available for this compound arises from experiments using cells isolated from rabbit and dog stomach [1-2], and therefore refers to the protein complexes forming the proton pump rather than to specific transporter subunits. |
Selectivity at ion channels | ||||||||||||||||||||||||||||||||||
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Selectivity at transporters | ||||||||||||||||||||||||||||||||||
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