DL-TBOA

Ligand id: 4631

Name: DL-TBOA

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 109.85
Molecular weight 239.08
XLogP -1.04
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Excitatory amino acid transporter 2 Inhibitor Inhibition 6.9 pKB - 2
pKB 6.9 (KB 1.2x10-7 M) [2]
Excitatory amino acid transporter 1 Inhibitor Inhibition 5.0 pKB - 2
pKB 5.0 (KB 9x10-6 M) [2]
Excitatory amino acid transporter 5 Inhibitor Inhibition 5.5 pKi - 1
pKi 5.5 (Ki 3.2x10-6 M) [1]
Excitatory amino acid transporter 4 Inhibitor Inhibition 5.4 pKi - 1
pKi 5.4 (Ki 4.4x10-6 M) [1]
Excitatory amino acid transporter 3 Inhibitor Inhibition 5.1 pIC50 - 3
pIC50 5.1 (IC50 8x10-6 M) [3]