dipyridamole

Ligand id: 4807

Name: dipyridamole

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View more information in the IUPHAR Pharmacology Education Project: dipyridamole, dipyridamole

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 12
Hydrogen bond donors 4
Rotatable bonds 12
Topological polar surface area 145.44
Molecular weight 504.32
XLogP -0.78
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
phosphodiesterase 7B Hs Inhibitor Inhibition 5.7 – 6.0 pIC50 - 3,6
pIC50 5.7 – 6.0 (IC50 1.99x10-6 – 1x10-6 M) [3,6]
phosphodiesterase 8A Hs Inhibitor Inhibition 5.1 pIC50 - 2
pIC50 5.1 (IC50 7.94x10-6 M) [2]
phosphodiesterase 8B Hs Inhibitor Inhibition 4.3 pIC50 - 5
pIC50 4.3 (IC50 5.01x10-5 M) [5]
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Equilibrative nucleoside transporter 1 Hs Inhibitor Inhibition 8.8 pKi - 4
pKi 8.8 (Ki 1.5x10-9 M) [4]
Plasma membrane monoamine transporter Hs Inhibitor Inhibition 5.9 pKi - 8
pKi 5.9 [8]
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields