dipyridamole

Ligand id: 4807

Name: dipyridamole

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 12
Hydrogen bond donors 4
Rotatable bonds 12
Topological polar surface area 145.44
Molecular weight 504.32
XLogP -0.78
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
phosphodiesterase 7B Inhibitor Inhibition 5.7 – 6.0 pIC50 - 3,6
pIC50 5.7 – 6.0 (IC50 1.99x10-6 – 1x10-6 M) [3,6]
phosphodiesterase 8A Inhibitor Inhibition 5.1 pIC50 - 2
pIC50 5.1 (IC50 7.94x10-6 M) [2]
phosphodiesterase 8B Inhibitor Inhibition 4.3 pIC50 - 5
pIC50 4.3 (IC50 5.01x10-5 M) [5]
Selectivity at human transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Equilibrative nucleoside transporter 1 Inhibitor Inhibition 8.8 pKi - 4
pKi 8.8 (Ki 1.5x10-9 M) [4]
Plasma membrane monoamine transporter Inhibitor Inhibition 5.9 pKi - 8
pKi 5.9 [8]
Targets where the ligand is described in the comment field
Target Comment
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