Abbreviated name: CNP
Synonyms: CNP-22
Compound class:
Endogenous peptide in human, mouse or rat
Comment: CNP is a a positive regulator of endochondral bone growth, and prevents dwarfism in mouse models of achondroplasia [2].
Species: Human
View more information in the IUPHAR Pharmacology Education Project: c-type natriuretic peptide |
Natural/Endogenous Targets | ||
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Selectivity at catalytic receptors | ||||||||||||||||||||||||||||||||||
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Additional information and targets (data relate to human unless otherwise stated) | ||
Description | Data | Reference |
Potency order at Guanylyl cyclase-A | atrial natriuretic peptide (NPPA, P01160) ≥ brain natriuretic peptide (NPPB, P16860) >> C-type natriuretic peptide (NPPC, P23582) | 1 |
Potency order at Guanylyl cyclase-B | C-type natriuretic peptide (NPPC, P23582) >> atrial natriuretic peptide (NPPA, P01160) >> brain natriuretic peptide (NPPB, P16860) | 1 |
Potency order at natriuretic peptide receptor 3 | atrial natriuretic peptide (NPPA, P01160) > C-type natriuretic peptide (NPPC, P23582) ≥ brain natriuretic peptide (NPPB, P16860) | 1 |