Ligand id: 5276

Name: sapropterin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 6
Rotatable bonds 2
Topological polar surface area 119.64
Molecular weight 241.12
XLogP -1.18
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Cofactor in Enzyme Reactions
Enzyme Reference
L-Phenylalanine hydroxylase
L-Tyrosine hydroxylase
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
L-Phenylalanine hydroxylase Hs Activator Activation 5.4 pKi - 2
pKi 5.4 (Ki 4x10-6 M) [2]
Description: Binding affinity for human PAH.
Ligand mentioned in the following text fields