AG 1296

Ligand id: 5915

Name: AG 1296

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 44.24
Molecular weight 266.11
XLogP 3.9
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
AG 1296 dose dependently inhibits autophosphorylation of both isoforms of the human PDGF receptor (PDGFRα and PDGFRβ) as determined by western blot [3].