compound 23e [PMID: 17929793]

Ligand id: 6346

Name: compound 23e [PMID: 17929793]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 82.7
Molecular weight 370.03
XLogP 1.98
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
mGlu1 receptor Rn Allosteric modulator Negative 8.8 pKi - 1
pKi 8.8 (Ki 1.5x10-9 M) [1]
mGlu1 receptor Hs Allosteric modulator Negative 8.5 pIC50 - 1
pIC50 8.5 (IC50 2.9x10-9 M) [1]