compound 23e [PMID: 17929793]

Ligand id: 6346

Name: compound 23e [PMID: 17929793]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 82.7
Molecular weight 370.03
XLogP 1.98
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
mGlu1 receptor Allosteric modulator Negative 8.5 pIC50 - 1
pIC50 8.5 (IC50 2.9x10-9 M) [1]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
mGlu1 receptor Allosteric modulator Negative 8.8 pKi - 1
pKi 8.8 (Ki 1.5x10-9 M) [1]