A-794278

Ligand id: 6354

Name: A-794278

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 64.68
Molecular weight 342.15
XLogP 2.84
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
mGlu1 receptor Allosteric modulator Negative 8.0 pIC50 - 1
pIC50 8.0 (IC50 1x10-8 M) [1]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
mGlu1 receptor Allosteric modulator Negative 8.3 pKi - 2
pKi 8.3 (Ki 5.4x10-9 M) [2]