compound 24d [PMID: 23357634]

Ligand id: 6366

Name: compound 24d [PMID: 23357634]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 50.69
Molecular weight 306.11
XLogP 3.24
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
mGlu5 receptor Allosteric modulator Negative 7.6 pIC50 - 1
pIC50 7.6 (IC50 2.3x10-8 M) [1]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
mGlu5 receptor Allosteric modulator Negative 7.5 pKi - 1
pKi 7.5 (Ki 3x10-8 M) [1]