Ligand id: 6369

Name: CPS125

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 109.43
Molecular weight 416.19
XLogP 5.02
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
TRPM8 Rn Activator Full agonist 4.5 pEC50 - 1
pEC50 4.5 [1]
Voltage: Physiological
Description: Whole-cell voltage-clamp recordings or Ca2+<.sup>-microfluorimetry in heterologous cells (HEK, CHO, and Xenopus oocytes) expressing TRPM8