compound 10 [PMID: 15482908]

Ligand id: 6449

Name: compound 10 [PMID: 15482908]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 96.07
Molecular weight 269.08
XLogP 1.76
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
mGlu5 receptor Rn Allosteric modulator Negative 7.7 pKi - 1
pKi 7.7 (Ki 1.9x10-8 M) [1]
mGlu5 receptor Hs Allosteric modulator Negative 7.1 pIC50 - 1
pIC50 7.1 (IC50 7.7x10-8 M) [1]