compound 21 [PMID: 22802221]

Ligand id: 6918

Name: compound 21 [PMID: 22802221]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 12
Topological polar surface area 126.91
Molecular weight 475.16
XLogP 5.54
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
AT2 receptor Rn Agonist Full agonist 5.6 – 5.8 pEC50 - 2
pEC50 5.6 – 5.8 [2]
AT2 receptor Hs Agonist Full agonist 4.8 pEC50 - 2
pEC50 4.8 [2]