alprazolam

Ligand id: 7111

Name: alprazolam

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 43.07
Molecular weight 308.08
XLogP 5.44
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
GABAA receptor α5 subunit Hs Allosteric modulator Positive 8.0 pEC50 - 1
pEC50 8.0 (EC50 1x10-8 M) [Binds to: benzodiazepine site] [1]
GABAA receptor α2 subunit Hs Allosteric modulator Positive 7.9 pEC50 - 1
pEC50 7.9 (EC50 1.2x10-8 M) [Binds to: benzodiazepine site] [1]
GABAA receptor α1 subunit Hs Allosteric modulator Positive 7.4 pEC50 - 1
pEC50 7.4 (EC50 3.7x10-8 M) [Binds to: benzodiazepine site] [1]
GABAA receptor α3 subunit Hs Allosteric modulator Positive 7.2 pEC50 - 1
pEC50 7.2 (EC50 6.9x10-8 M) [Binds to: benzodiazepine site] [1]