Ligand Id: 724
Ligand name L-lysine

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 89.34
Molecular weight 146.11
XLogP -2.95
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands
Transporters
Transporter DB page EC number Reaction Reference
Mitochondrial ornithine transporter 2 View in GRAC 1
Cationic amino acid transporter 3 View in GRAC
Mitochondrial ornithine transporter 1 View in GRAC 1
High affinity cationic amino acid transporter 1 View in GRAC
Low affinity cationic amino acid transporter 2 View in GRAC
SNAT4 View in GRAC 3

Selectivity data from the Guide to Receptors and Channels (GRAC), 5th Edition.

Rank order of potency at human receptors (unless otherwise stated)
Description Rank order of potency Reference
Substrates at SNAT4 L-histidine > L-arginine, L-alanine, L-asparagine, L-lysine > glycine, L-glutamine, L-serine, L-proline, L-leucine, L-phenylalanine 3

Selectivity data from IUPHAR-DB

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
GPRC6 receptor Agonist Full agonist 3.8 pEC50 - 2

Please note: The activity data given on this ligand page represents selected literature values and may not include all reported data.
For more details please contact: curators@iuphar-db.org