Ligand id: 730

Name: CP55940

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 60.69
Molecular weight 376.3
XLogP 7.46
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
CP55940 shows high affinity for the orphan GPCR, GPR55, and it has been suggested that GPR55 may be a new cannabinoid receptor [5]. Experimental evidence reported by Kapur et al. (2009) suggests that CP55940 is an antagonist/partial agonist of GPR55 [4].
Selectivity at Human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
CB2 receptor Agonist Full agonist 8.6 – 9.2 pKi - 3,6,8
pKi 8.6 – 9.2 [3,6,8]
CB1 receptor Agonist Full agonist 8.3 – 9.2 pKi - 3,6,8
pKi 8.3 – 9.2 [3,6,8]
GPR55 Agonist Agonist 8.3 pEC50 - 1,7
pEC50 8.3 (EC50 5x10-9 M) [1,7]