triazolam

Ligand id: 7313

Name: triazolam

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 43.07
Molecular weight 342.04
XLogP 5.12
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
GABAA receptor α1 subunit Allosteric modulator Positive 9.0 pKd - 1
pKd 9.0 (Kd 1x10-9 M) [1]
Description: Binding affinity to GABAA α1β2γ2 receptor.
GABAA receptor α5 subunit Allosteric modulator Positive 8.4 pKd - 1
pKd 8.4 (Kd 4x10-9 M) [1]
Description: Binding affinity to GABAA receptor α5β2γ2.
GABAA receptor α2 subunit Allosteric modulator Positive 9.2 pKi - 2
pKi 9.2 (Ki 5.9x10-10 M) [2]
Description: Binding affinity to human recombinant GABAA receptor α2β3γ2.
GABAA receptor α1 subunit Allosteric modulator Positive 9.1 pKi - 2
pKi 9.1 (Ki 8x10-10 M) [2]
Description: Binding affinity for human recombinant GABAA receptor α1β3&gamma,2.
GABAA receptor α3 subunit Allosteric modulator Positive 8.8 pKi - 2
pKi 8.8 (Ki 1.43x10-9 M) [2]
Description: Binding affinity to human recombinant GABAA receptor α3β3γ2.
GABAA receptor α5 subunit Allosteric modulator Positive 8.8 pKi - 2
pKi 8.8 (Ki 1.54x10-9 M) [2]
Description: Binding affinity for human recombinant GABAA receptor α5β3γ2.