WIN55212-2

Ligand id: 733

Name: WIN55212-2

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 43.7
Molecular weight 426.19
XLogP 5.93
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
CB2 receptor Hs Agonist Full agonist 8.4 – 9.6 pKi - 1-3
pKi 8.4 – 9.6 [1-3]
CB1 receptor Hs Agonist Full agonist 6.9 – 8.7 pKi - 1-3
pKi 6.9 – 8.7 [1-3]
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
glycine receptor α3 subunit Hs Antagonist Antagonist 7.0 pIC50 -
pIC50 7.0 (IC50 9.7x10-8 M)
Glycine Receptor (All subtypes) N/A Subunit-specific Inhibition 6.7 – 7.0 pIC50 < 1x10-6 4
pIC50 6.7 – 7.0 Conc range: < 1x10-6 M α3>α2, no inhibition of α1 [4]
glycine receptor α2 subunit Hs Antagonist Antagonist 6.7 pIC50 -
pIC50 6.7 (IC50 2.2x10-7 M)