ribociclib

Ligand id: 7383

Name: ribociclib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 91.21
Molecular weight 434.25
XLogP 1.76
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Treatment with nanomolar concentrations of ribociclib reduces proliferation in human neuroblastoma-derived cell lines (mean IC50 307nM) and in mouse xenograft models [8].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
cyclin dependent kinase 4 Inhibitor Inhibition 8.0 pIC50 - 3
pIC50 8.0 (IC50 1x10-8 M) [3]