Ligand id: 7465

Name: dronedarone

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View more information in the IUPHAR Pharmacology Education Project: dronedarone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 18
Topological polar surface area 97.23
Molecular weight 556.3
XLogP 7.46
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Effects of dronedarone on atrial fibrilation are generally assessed in in vivo animal studies [4-5], or its effect on channel conductance measured in patch clamp experiments [1]. Since affinity/efficacy data for dronedarone at specific human molecular targets is scarce in the scientific literature, and due to the poly-pharmacology and complex and incompletely defined molecular mechanism of action we have not tagged a primary drug target for dronedarone.
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Kv1.5 Hs Inhibitor Inhibition 5.6 pIC50 - 2
pIC50 5.6 (IC50 2.37x10-6 M) [2]
Description: Whole cell patch clamp experiment using HEK293 cells expressing human Kv1.5.