Ligand id: 7559

Name: zuclopenthixol

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View more information in the IUPHAR Pharmacology Education Project: zuclopenthixol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 52.01
Molecular weight 400.14
XLogP 3.89
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Zuclopenthixol (cis(Z)-cloflupentixol) blocks contralateral circling behaviour in unilaterally 6-hydroxy-dopamine lesioned rats stimulated by either dopamine D1 or D2 receptor agonists [1], supporting its antagonist effects at both receptor subtypes. PET imaging in human subjects shows zuclopenthixol occupancy of dopamine D2 receptors at concentrations high enough to cause sedation [2]. As there appears to be no publicly available affinity data for this drug at its human molecular targets we have not mapped primary drug targets in this instance.