Synonyms: Levoprome® | methotrimeprazine | Nosinan® | Nozinan® | RP-7044 | SK&F-5116
levomepromazine is an approved drug
Compound class:
Synthetic organic
Comment: Marketed formulations contain either levomepromazine hydrochloride or levomepromazine maleate.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: levomepromazine |
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Bioactivity Comments |
In in vitro investigations using human brain homogenate, levomepromazine (aka methotrimeprazine in the study) displaced [3H]doxepin (a high potency histamine H1 receptor antagonist) with a Kd value of 0.58nM [2]. In rat brain striatal preparations levomepromazine diplaced [3H]sulpiride binding (ie to the D2 dopamine receptor) with an IC50 value of 17nM [1]. |