Ligand id: 7603

Name: levomepromazine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 41.01
Molecular weight 328.16
XLogP 4.21
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
In in vitro investigations using human brain homogenate, levomepromazine (aka methotrimeprazine in the study) displaced [3H]doxepin (a high potency histamine H1 receptor antagonist) with a Kd value of 0.58nM [2]. In rat brain striatal preparations levomepromazine diplaced [3H]sulpiride binding (ie to the D2 dopamine receptor) with an IC50 value of 17nM [1].