Ligand id: 7626

Name: cobimetinib

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 64.6
Molecular weight 531.06
XLogP 4.65
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
mitogen-activated protein kinase kinase 1 Hs Allosteric modulator Negative 9.1 pIC50 - 3
pIC50 9.1 (IC50 9x10-10 M) [3]
Description: Biochemical assay measuring MEK-induced phosphorylation of ERK residues T202 and Y204.
mitogen-activated protein kinase kinase 2 Hs Allosteric modulator Negative 6.7 pIC50 - 3
pIC50 6.7 (IC50 1.99x10-7 M) [3]
mitogen-activated protein kinase kinase 7 Hs Allosteric modulator Negative <5.0 pIC50 - 3
pIC50 <5.0 (IC50 >1x10-5 M) [3]