Ligand id: 7663

Name: CX4

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 56.15
Molecular weight 380.11
XLogP 9.3
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at Mouse ion channels
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Target Type Action Affinity Units Concentration range (M) Reference
Kv12.2 Gating inhibitor Inhibition 5.0 pIC50 - 1
pIC50 5.0 [1]
Voltage: -20.0 mV
Description: 10 µM CX4 depolarizes voltage dependence of activation by ~+40 mV
Conditions: Voltage clamp of CHO cells heterologously expresing Kv12.2.