CX4

Ligand id: 7663

Name: CX4

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 56.15
Molecular weight 380.11
XLogP 9.3
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Kv12.2 Mm Gating inhibitor Inhibition 5.0 pIC50 - 1
pIC50 5.0 [1]
Voltage: -20.0 mV
Description: 10 µM CX4 depolarizes voltage dependence of activation by ~+40 mV
Conditions: Voltage clamp of CHO cells heterologously expresing Kv12.2.