Ligand id: 7734

Name: AZ12419304

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 88.91
Molecular weight 453.14
XLogP 4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Bioactivity Comments
Affinity measurements from patent WO2007113558 A2 gives this compound an IC50 of 44nM against full length His-tagged B-Raf carrying the V600E mutation (VAR_018629).