Synonyms: LCQ-908 | LCQ908
Compound class:
Synthetic organic
Comment: Pradigastat is a potent and selective inhibitor of diacylglycerol O-acyltransferase 1 (DGAT1).
The PubChem CID 53387035 shows the molecule with no stereochemistry. Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
Bioactivity Comments |
Results of a Phase II study report that pradigastat at doses >10mg can reduce postprandial triglyceride levels in obese diabetic patients (presented as abstract MEDI 230 at the ACS 243rd National Meeting and Exposition, San Diego, March 2012; see also the results as collated on the Novartis Clinical Trial Results Database [2]). In a separate trial which treated patients with familial chylomicronemia syndrome with pradigastat for 3 weeks, a >38% reduction in plasma triglycerides was reported [1]. |