Synonyms: histone deacetylase inhibitor VI
Compound class:
Synthetic organic
Comment: HNHA is a novel histone deacetylase (HDAC) inhibitor with potential anti-tumour and anti-liver fibrosis activity [1-2].
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Bioactivity Comments |
HNHA inhibits HDAC activity in a cellular extract with an IC50 value of 100nM [1]. HNHA is dose-dependently cytotoxic to mouse hepatic stellate cells (HSCs), via induction of cell cycle arrest [2] caused by inhibition of HSC survival molecules and pro-apoptotic signalling pathway components. HNHA inhibits proliferation of human HSCs with an IC50 of 12μM [2] (15μM for mouse HSCs). In vivo, HNHA increases survival in the BDL-induced rat liver fibrosis model [2]. |