amuvatinib

Ligand id: 7932

Name: amuvatinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 107.98
Molecular weight 447.14
XLogP 3.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Amuvatinib inhibits the in vitro phosphorylation of tyrosine residues in c-KIT and AXL [2]. Patent derived data for mutant kinases, using the hydrochloride salt, provides IC50 values for c-KitD816H, c-KITV560G, PDGFRαD842V and PDGFRαV561D of 10nM, 34nM, 81nM and 40nM respectively [1].