amifampridine

Ligand id: 8032

Name: amifampridine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 0
Topological polar surface area 64.93
Molecular weight 109.06
XLogP -0.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Administered clinically as the phosphate salt (PubChem CID 9920716).
In a mouse model of LEMS, amifampridine significantly increases the magnitude of acetylcholine release from ex-vivo neuromuscular junctions [3], compared to vehicle control.