compound 13d [PMID: 23639540]

Ligand id: 8120

Name: compound 13d [PMID: 23639540]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 55.55
Molecular weight 407.17
XLogP 4.06
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
activin A receptor type IL Inhibitor Inhibition >8.3 pIC50 - 1
pIC50 >8.3 (IC50 <5x10-9 M) [1]
activin A receptor type 1 Inhibitor Inhibition >8.3 pIC50 - 1
pIC50 >8.3 (IC50 <5x10-9 M) [1]
bone morphogenetic protein receptor type IA Inhibitor Inhibition >8.3 pIC50 - 1
pIC50 >8.3 (IC50 <5x10-9 M) [1]
bone morphogenetic protein receptor type IB Inhibitor Inhibition >8.3 pIC50 - 1
pIC50 >8.3 (IC50 <5x10-9 M) [1]
transforming growth factor beta receptor 2 Inhibitor Inhibition 7.6 pIC50 - 1
pIC50 7.6 (IC50 2.6x10-8 M) [1]
transforming growth factor beta receptor 1 Inhibitor Inhibition 6.8 pIC50 - 1
pIC50 6.8 (IC50 1.78x10-7 M) [1]
activin A receptor type 1B Inhibitor Inhibition 6.5 pIC50 - 1
pIC50 6.5 (IC50 3.26x10-7 M) [1]