compound 22m [PMID: 19831390]

Ligand id: 8153

Name: compound 22m [PMID: 19831390]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 4
Rotatable bonds 8
Topological polar surface area 145.56
Molecular weight 461.23
XLogP 2.04
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Although compound 22m is a potent inhibitor of LIMK2 it was not screened against any other kinases, so its selectivity profile is not known.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
LIM domain kinase 2 Hs Inhibitor Inhibition 9.1 pIC50 - 1
pIC50 9.1 (IC50 8x10-10 M) [1]