compound 7k [PMID: 23521020]

Ligand id: 8164

Name: compound 7k [PMID: 23521020]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 59.29
Molecular weight 386.09
XLogP 5.74
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Compound 7k is equipotent at the receptor tyrosine kinase c-KIT, but has no other significant off-targets [1].
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
discoidin domain receptor tyrosine kinase 1 Inhibitor Inhibition 8.6 pIC50 - 1
pIC50 8.6 (IC50 2.29x10-9 M) [1]
KIT proto-oncogene receptor tyrosine kinase Inhibitor Inhibition 8.3 pIC50 - 1
pIC50 8.3 (IC50 4.89x10-9 M) [1]