compound 5m [PMID: 20483621]

Ligand id: 8206

Name: compound 5m [PMID: 20483621]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 51.71
Molecular weight 583.23
XLogP 6.59
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
In a selectivity profile screen only 5% of the kinases tested were inhibited by >90% by 1μM compound 5m [1] (see the article's Supplementary data).
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
BMP2 inducible kinase Hs Inhibitor Inhibition - - - 1
[1]
Description: Measured as % inhibition using 1μM compound.
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
ALK receptor tyrosine kinase Hs Inhibitor Inhibition 8.0 pIC50 - 1
pIC50 8.0 (IC50 1x10-8 M) [1]