compound 5g [PMID: 20483621]

Ligand id: 8207

Name: compound 5g [PMID: 20483621]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 47.53
Molecular weight 468.16
XLogP 3.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
In a selectivity profile screen only 2% of the kinases tested were inhibited by >90% by 1μM compound 5g [1] (see the article's Supplementary data).
Selectivity at human enzymes
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Target Type Action Affinity Units Concentration range (M) Reference
doublecortin like kinase 1 Inhibitor Inhibition - - - 1
[1]
Description: Measured as % inhibition using 1μM compound.
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
ALK receptor tyrosine kinase Inhibitor Inhibition 8.0 pIC50 - 1
pIC50 8.0 (IC50 1.1x10-8 M) [1]