Ligand id: 8424

Name: BF-1

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 47
Molecular weight 367.16
XLogP 3.65
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Binding affinities for BF-1 across the serotinin receptor family and a range of non-serotonin monoaminergic receptors are reported in [1]. We show the affinity for the 2A subtype as the next closest affinity to the 2B receptor in the table below. All other receptors tested had lower affinities for BF-1.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
5-HT2B receptor Hs Antagonist Antagonist 10.1 pKi - 1
pKi 10.1 [1]
5-HT2A receptor Hs Antagonist Antagonist 8.6 pKi - 1
pKi 8.6 [1]