EMD-386088

Ligand id: 8428

Name: EMD-386088

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 27.82
Molecular weight 246.09
XLogP 2.37
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
The pharmacological profile of EMD 386088 across 5-HT receptor subtypes is provided by Mattson et al. (2005; Table 4) [1].
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
5-HT6 receptor Hs Agonist Agonist 8.1 pIC50 - 1
pIC50 8.1 (IC50 7.4x10-9 M) [1]