A-381393

Ligand id: 8441

Name: A-381393

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 35.16
Molecular weight 320.2
XLogP 4.49
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
A-381393 is >2700-fold selective for the D4 receptor compared to the D1, D2, D3 and D5 receptors [1].
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
D4 receptor Antagonist Antagonist 8.8 pKi - 1
pKi 8.8 (Ki 1.5x10-9 M) [1]