BAZ2-ICR

Ligand id: 8571

Name: BAZ2-ICR

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 77.25
Molecular weight 357.17
XLogP 1.61
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
BAZ2-ICR is > 100-fold selective for the BAZ2A/B BRDs compared to those of other bromodomain-containing proteins. Notably the compound is only 15-fold selective for BAZ2A/B compared to CECR2 (cat eye syndrome chromosome region, candidate 2).
Selectivity at human other protein targets
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
bromodomain adjacent to zinc finger domain 2A Inhibitor Inhibition 7.0 pKd - 1
pKd 7.0 (Kd 1.09x10-7 M) [1]
Description: Isothermal titration calorimetry (ITC) assay
bromodomain adjacent to zinc finger domain 2B Inhibitor Inhibition 6.8 pKd - 1
pKd 6.8 (Kd 1.7x10-7 M) [1]
Description: Isothermal titration calorimetry (ITC) assay