compound 57 [PMID: 16610804]

Ligand id: 8771

Name: compound 57 [PMID: 16610804]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 18
Topological polar surface area 104.06
Molecular weight 523.26
XLogP 7.05
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
cPLA2-4A Inhibitor Inhibition 8.4 pIC50 - 1
pIC50 8.4 (IC50 4.3x10-9 M) [1]
Description: Inhibition of human isolated cPLA2-4A in a lipid vesicle assay.